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Cardiac Imaging Research


Message from the Director

Jane Cao, M.D. 

We have research protocols in cardiac MRI, CT, echo and PET including some in the most innovative areas of cardiac imaging such as computational fluid dynamics, deep machine learning and artificial intelligence, fast cardiac MR imaging, 4D blood flow imaging and 3D printing. Our research goal in cardiac imaging is to improve diagnostic accuracy and to achieve precision in medicine. 

Cardiac Imaging Research Protocols

   Title of Study                                                                    Principal Investigator

The determinants of recovery of myocardial function in patients with heart failure

J. Jane Cao, MD; Rita Jermyn, MD

Comparison of Myocardial CT perfusion with Coronary Fraction Flow Reserve by CTA

Timothy Christian, MD

The Assessment of blood flow within the left atrial appendage by 4D MRI

Timothy Christian, MD

Real-time pediatric cardiovascular MRI without breath holding, ECG monitoring or respiratory navigation

Yu Yulee Li, PhD

Comparisons of Coronary Artery Plaque Characteristics by MRI, CT and Optical Coherence Tomography

Jane Cao, MD; Richard Shlofmitz, MD

Advanced Cardiac Imaging in Detection of Cardiotoxicity of Cancer Chemotherapy

Nathaniel Reichek, MD

A New Echocardiographic-Based Method for Evaluation of Aortic Valve Calcification in Patients with Aortic Valve Stenosis

Eddy Barasch, MD

Physiologic Determinants of Myocardial Strain (formerly Effects of Afterload, Ventricular Remodeling and Myocardial Composition on Myocardial Straining)

Nathaniel Reichek, MD

Assessing Pulmonary Perfusion Reserve by Cardiac MRI

J. Jane Cao, MD

Assessment of myocardial tissue properties, hemodynamics and mechanical performance by cardiac MRI

J. Jane Cao, MD

Recent publications in the area of Cardiac Imaging

Maurer M, Bartz T, Hoe Koh, WJ, Barasch E, Gardin J, Psaty B, Gottdiener J, Jorge K.

Association of the myocardial contraction fraction, as calculated from two-dimensional echocardiography, with incident heart failure, atherosclerotic cardiovascular disease and mortality: The Cardiovascular Health Study. AM J Cardiol 2017:119(6):923-928 

Massera D, Xu S, Bartz TM, Bortnick AE, Ix JH, Chonchol M, Owens DS, Barasch E, Gardin JM, Gottdiener JS, Robbins JR, Siscovick DS, Kizer JR. Relationship of bone mineral density with valvular and annular calcification in community-dwelling older people: The Cardiovascular Health Study. Arch of Osteroporosis   doi: 10.1007/s11657-017-0347-y. Epub 2017 May 30, 12(1):52 

Cao JJ, Li Y, McLaughlin J, Passick M. Prolonged central circulation transit time in patients with HFpEF and HFeEF by magnetic resonance imaging. EUR Heart J Cardiovasc Imaging (2018), 19(3):339-346. 

Zhinuo JW, Wang VY, Bradley CP, Nash MP, Young AA and Cao, JJ. Left Ventricular Diastolic myocardial stiffness and end-diastolic myofibre stress in human heart failure using personalised biomechanical analysis. J Cardiovasc Transl Res (2018). 

Cao JJ, Ngai N, Duncanson L, Cheng J, Gliganic K and Chen Q. A comparison of both DENSE and feature tracking techniques with tagging for the cardiovascular magnetic resonance assessment of myocardial strain. J Cardiovasc Magn Reson (2018), 20(1):26 

Kwong RY, Petersen SE, Schulz-Menger J, Arai AE, Bingham SE, Chen Y, Choi YL, Cury RC, Ferreira VM, Flamm SD, Steel K, Bandettini WP, Martin ET, Nallamshetty L, Neubauer S, Raman SV, Schelbert EB, Valeti US, Cao JJ, Reichek N, Young AA, Fexon L, Pivovarov M, Ferrari VA, Simonetti OP. The global cardiovascular magnetic resonance registry (GCMR) of the society for cardiovascular magnetic resonance (SCMR): its goals, rationale, data infrastructure, and current developments. J Cardiovasc Magn Reson (2017), 19(1):23. 

Goeller M; Achenbach S; Marwan M; Doris MK; Cadet S; Commandeur F; Chen X; Slomka PJ;  Gransar H; JJ Cao; Wong ND; Albrecht MH; Tamarappoo BK; Berman DS; Dey D. Epicardial fat volume is related to early subclinical atherosclerosis and inflammation in asymptomatic subjects J Cardiovasc CT 2017:12(1):67-73. 

Saha SK, Gopal AS, Govind SC, Fang F, Liu M, Zhang Q, Ma C, Dong M, Kiotsekoglou A, Luo X, Yu CM. Incremental prognostic value of multi-chamber deformation imaging and renal function for outcome determination in heart failure with reduced ejection fraction.Echocardiography (2018), 35(4):450-458 

Yu Li, Masoud Edalati, Xingfu Du, Hui Wang, JJ Cao. Self-calibrated correlation imaging with k-space variant correlation functions.Magn Reson Med (2018), 79(3):1483-1494. 

LI Y, Rashid S, Chenga YJ, Schapiro W, Gliganic K, Yamashita A, Tang J, Grgas M, Mendez M, Haag E, Pangc J, Stoeckelc B, Leideckerc C , Cao JJ. Real-time cardiac MRI with radial acquisition and k-space variant reduced-FOV reconstruction. MRI 2018:53:98-104 

Zhang P, Wang F, Xu W, and Li Y. Multi-channel Generative Adversarial Network for Parallel Magnetic Resonance Imaging Reconstruction in k-space. MICCAI 2018. 

Van Tosh A, Votaw JR, Cooke CD, Reichek N, Palestro CJ, Nichols KJ. Relationships between left ventricular asynchrony and myocardial blood flow. J Nucl Cardiol (2017), 24(1):43-52. 

Van Tosh A, Reichek N, Cooke CD, Palestro CJ, Nichols KJ. Rb-82 PET/CT left ventricular mass-to-volume ratios. Int J Cardiovasc Imaging (2017), 33(8):1263-1270. 

Van Tosh A, Votaw J, Cooke CD, Cao, JJ, Palestro CJ, Nichols KJ. Relationship of 82Rb PET territorial myocardial asynchrony to arterial stenosis. J. Nucl cardiol 2018.