The Association between Left Ventricular Diastolic Dysfunction and Myocardial Scar and Their Collective Impact on All-Cause Mortality
Lin Wang, Harsimar Singh, Rajasekhar R. Mulyala, Jonathan Weber, Eddy Barasch, J Jane Cao.
By Anne Li, Research Assistant
Heart failure is a leading contributing cause of death around the world, and St. Francis Hospital is at the forefront of cutting-edge cardiac research that aims to ultimately improve patients’ outlook and experience. Led by Dr. Lin Wang and Dr. J. Jane Cao, Imaging Cardiologists at St. Francis, this large single-center study investigated the link between left ventricular diastolic dysfunction and myocardial scar, and their combined contribution to all-cause mortality. Diastolic dysfunction is a known contributing cause of heart failure and mortality, and the presence of myocardial scar detected by cardiac magnetic resonance (CMR) also portends increased risk of morbidity and mortality. This study is the first of its kind to investigate the relationship and cumulative impact of diastolic dysfunction and myocardial scar on mortality, in a large number of patients spanning more than 600 subjects. The study found that diastolic dysfunction was associated with higher incidence and greater extent of myocardial scarring, patients with both diastolic dysfunction and scarring were at the highest mortality risk, and tissue characterization enhanced risk stratification for patients with diastolic dysfunction.
Exciting future steps could include expanding the study across multiple centers and population groups, and focusing on development of therapy to treat diastolic dysfunction and prevent myocardial scarring.