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Accuracy of Fractional Flow Reserve Derived From Coronary Angiography


Fearon, W.F., Achenbach, S., Engstrom, T., Assali, A., Shlofmitz, R., Jeremias, A., Fournier, S., Kirtane, A.J., Kornowski, R., Greenberg, G., Jubeh, R., Kolansky, D.M., McAndrew, T., Dressler, O., Maehara, A., Matsumura, M., Leon, M.B., De Bruyne, B., & FAST-FFR Study Investigators.

By Jonathan Scheiner, Research Assistant

As published in Circulation, the FAST-FFR study has highlighted the success of fractional flow reserve (FFR) measurement via coronary angiography, termed FFRangio, as compared to traditional FFR methods. At St. Francis Hospital, more research participants were enrolled than at any other center. Under the guidance of Dr. Richard Shlofmitz and Dr. Allen Jeremias,, St. Francis contributed significantly to this international, multicenter study. Pairing conventional coronary angiography with advanced computer processing software, FFRangio measurement provides physicians “a 3D reconstruction of the entire coronary tree with FFR values along each vessel (Fearon et al., Circulation 2019)”, allowing for the highly effective assessment of a patient’s coronary system. As compared to traditional FFR, FFRangio measurement saves time and costs by using computational fluid dynamics; unlike traditional FFR, FFRangio does not require the insertion of vessel-specific pressure wires or administration of vasodilating medication, potentially leading to significantly improved patient experiences and avoiding potential procedure-related risks. With a reported diagnostic sensitivity, specificity, and accuracy over 90%, and with a device success rate of 99%, FFRangio technology has the potential to replace pressure wire-derived FFR methods in the cardiac catheterization lab for patients with suspected coronary artery disease.