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Structural Heart Disease Research


Enthusiasm from the Directors

George Petrossian, M.D. and Newell Robinson, M.D.

The research conducted through the Heart Valve Center is focused on moving the boundaries of what is possible through a combination of technologic advances and clinical experience. We have accomplished much in the therapy of aortic valve disease with TAVR, and are just beginning our journey in the therapy of mitral and tricuspid valve disease. 

Structural Heart Research Protocols 

Title of Study                                                                         Principal Investigator

Annular Reduction for Transcatheter Treatment of Insufficient Mitral Valve (ACTIVE) ( CARDIOBAND )

George A. Petrossian, MD

APOLLO Trial : Transcatheter Mitral Valve Replacement with the Medtronic Intrepid™ TMVR System in patients with severe symptomatic mitral regurgitation

George A. Petrossian, MD

Newell Robinson, MD

Transcatheter Aortic Valve Replacement With the Medtronic Transcatheter Aortic Valve Replacement System In Patients at Low Risk for Surgical Aortic Valve Replacement-LRT

George A. Petrossian, MD

Newell Robinson, MD

The REFLECT I Trial: A Randomized Evaluation of the TriGuard HDH Embolic Deflection Device to Reduce the Impact of Cerebral Embolic Lesions after Transcatheter Aortic Valve Implantation

George Petrossian, MD

Early Feasibility Study of the CardiAQ-Edwards Transcatheter Mitral Valve (TMV) System for the Treatment of Moderate to Severe Mitral Regurgitation

George Petrossian, MD Newell Robinson, MD

TAVR UNLOAD Transcatheter Aortic Valve Replacement to unload the left ventricle in patients with advanced heart failure: a randomized trial.

George Petrossian, MD

COAPT : Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional MR (COAPT) Continued Access Study

Andrew D. Berke, MD

Recent publications in the area of Structural Heart Disease (2017- June 2018)

Little SH, Popma JJ, Kleiman NS, Deeb GM, Gleason TG, Yakubov SJ, Checuti S, O'Hair D, Bajwa T, Mumtaz M, Maini B, Hartman A, Katz S, Robinson N, Petrossian G, Heiser J, Merhi W, Moore BJ, Li S, Adams DH, Reardon MJ. Transcatheter aortic valve replacement in patients with severe mitral or tricuspid regurgitation at extreme risk for surgery. J Thorac Cardiovasc Surg. 2018 May;155(5):1991-1999.  

Deeb GM, Chetcuti SJ, Yakubov SJ, Patel HJ, Grossman PM, Kleiman NS, Heiser J, Merhi W, Zorn GL 3rd, Tadros PN, Petrossian G, Robinson N, Mumtaz M, Gleason TG, Huang J, Conte JV, Popma JJ, Reardon MJ. Impact of annular size on outcomes after surgical or transcatheter aortic valve replacement. Ann Thorac Surg. 2018 Apr;105(4):1129-1136. 

O'Hair DP, Bajwa TK, Popma JJ, Watson DR, Yakubov SJ, Adams DH, Sharma S, Robinson N, Petrossian G, Caskey M, Byrne T, Kleiman NS, Zhang A, Reardon MJ. Direct aortic access for transcatheter aortic valve replacement using a self-expanding device. Ann Thorac Surg. 2018 Feb;105(2):484-490. 

Deeb GM, Chetcuti SJ, Reardon MJ, Patel HJ, Grossman PM, Schreiber T, Forrest JK, Bajwa TK, O'Hair DP, Petrossian G, Robinson N, Katz S, Hartman A, Dauerman HL, Schmoker J, Khabbaz K, Watson DR, Yakubov SJ, Oh JK, Li S, Kleiman NS, Adams DH, Popma JJ.1-Year results in patients undergoing transcatheter aortic valve replacement with failed surgical bioprostheses. JACC Cardiovasc Interv. 2017 May 22;10(10):1034-1044. 

O'Hair DP, Bajwa TK, Chetcuti SJ, Deeb GM, Stoler RC, Hebeler RF, Maini B, Mumtaz M, Kleiman NS, Reardon MJ, Li S, Adams DH, Watson DR, Yakubov SJ, Popma JJ, Petrossian G.

One-year outcomes of transcatheter aortic valve replacement in patients with end-stage renal disease. Ann Thorac Surg. 2017 May;103(5):1392-1398.