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Prolonged central circulation transit time in patients with HFpEF and HFrEF by magnetic resonance imaging

By Anne Li, Research Assistant

The study was published in the European Heart Journal – Cardiovascular Imaging (2018) and was led by Dr. Jane Cao, Director of Research and Cardiac Imaging at St. Francis. There have been extensive studies investigating the relationship between HF and prolongation of central circulation transit time (TT), which has been long associated with HF and left ventricular (LV) dysfunction. However, there has been a paucity of work focusing on the regional circulation TT between central cardiovascular structures in HF. Furthermore, the circulation TT delay in HF patients with preserved ejection fraction (HFpEF) is not well
understood. Overall, this study aimed to examine the relationship between global and regional central TT, and left and right heart hemodynamics in HF patients.

The study recruited 58 volunteers from St. Francis who underwent cardiac MRI (CMR). Overall, global central TT was found to be significantly prolonged in HF patients, with an average 42% increase in HFpEF patients and 102% increase in HFrEF patients. The study was also able to conclude that prolonged central TT in HFpEF patients does not arise solely from cardiac function, and that
hemodynamic abnormalities associated with left HF were the essential determinants of prolonged TT in HF patients.

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