Interventional Cardiology Research

Vision from the Chairman

Richard Shlofmitz, M.D.

Interventional Cardiology has been around for over 30 years. But it's starting a new chapter in its history. With the use of physiology and intravascular imaging, we're now able to determine which patients need to have an intervention to help them for their angina and prolong their life as well as using precision angioplasty to guarantee the best results possible. With precision angioplasty we can assess the morphology of the lesion so we can treat it appropriately. We can determine the exact length of the stent needed to custom tailor what the patient needs, length, size and exact placement. In addition, when the procedure is completed, we can be sure that the stent is placed accurately with the stent having the right size with no complications related to the insertion of the stent. With both physiology and imaging, St Francis is one of the world's leader in this technique and is involved in many of the important trials that deal with this technology. St Francis is continually involved in ground breaking studies with new technology to further advance the care of our patients and remain one of the worldwide leaders in interventional cardiology. 

Interventional Research Protocols

 Title of Study                                                                    Principal Investigator

ILUMIEN IV: OPTIMAL PCI - Optical Coherence Tomography (OCT) Guided Coronary Stent Implantation Compared to Angiography:  a Multicenter Randomized Trial in PCI

Richard A. Shlofmitz, MD

XIENCE 90: 3-month dual antiplatelet therapy (DAPT) in subjects at high risk of bleeding (HBR) undergoing percutaneous coronary intervention (PCI) with XIENCE.

Jeffrey Moses, MD

PRECISION study: Optical computed tomography-versus intravascular ultrasound-and angiography-guided percutaneous intervention in patients with stable or unstable coronary artery disease

Allen Jeremias, MD

DEFINE-PCI : Physiologic assessment of coronary stenosis following PCI

Richard A. Shlofmitz, MD

ECLIPSE:  Evaluation of  treatment strategies for severe calcific coronary arteries: Oribital Atherectomy vs. Conventional Angioplasty Technique prior to implantation of drug-eluting stents

Richard A. Shlofmitz, MD

Recent publications in the area of Interventional Cardiology (2017- June 2018)

 Yamamoto MH, Maehara A, Song L, Matsumura M, Chin CY, Losquadro M, Sosa FA, Mintz GS, Shlofmitz RA. Optical coherence tomography assessment of morphological characteristics in suspected coronary artery disease, but angiographically nonobstructive lesions. Cardiovasc Revasc Med. 2018 Jul 24. pii: S1553-8389(18)30310-5. [Epub ahead of print] 

Shlofmitz E, Shlofmitz RA, Galougahi KK, Rahim HM, Virmani R, Hill JM, Matsumura M, Mintz GS, Maehara A, Landmesser U, Stone GW, Ali ZA. Algorithmic Approach for Optical Coherence Tomography-Guided Stent Implantation During Percutaneous Coronary Intervention. Interv Cardiol Clin. 2018 Jul;7(3):329-344. 

Lee MS, Shlofmitz E, Park KW, Goldberg A, Jeremias A, Shlofmitz R. Orbital Atherectomy of Severely calcified unprotected left main coronary artery disease: One-year outcomes.

J Invasive Cardiol. 2018 Jul;30(7):270-274. 

Lee MS, Shlofmitz E, Lluri G, Park KW, Hollowed J, Shlofmitz R. One-Year Outcomes of Orbital Atherectomy of long, diffusely calcified coronary artery lesions. J Invasive Cardiol. 2018 Jun;30(6):230-233. 

Fujino A, Mintz GS, Lee T, Hoshino M, Usui E, Kanaji Y, Murai T, Yonetsu T, Matsumura M, Ali ZA, Jeremias A, Moses JW, Shlofmitz RA, Kakuta T, Maehara A. Predictors of calcium fracture derived from balloon angioplasty and its effect on stent expansion assessed by optical coherence tomography. JACC Cardiovasc Interv. 2018 May 28;11(10):1015-1017. 

Shlofmitz E, Sosa F, Goldberg A, Maehara A, Ali ZA, Mintz GS, Moses JW, Stone GW, Shlofmitz RA, Jeremias A. Bifurcation and ostial optical coherence tomography mapping (BOOM) - Case description of a novel bifurcation stent technique. Cardiovasc Revasc Med. 2018 May 6. pii: S1553-8389(18)30185-4. [Epub ahead of print] 

Lee T, Shlofmitz RA, Song L, Tsiamtsiouris T, Pappas T, Madrid A, Jeremias A, Haag ES, Ali ZA, Moses JW, Matsumura M, Mintz GS, Maehara A. The effectiveness of excimer laser angioplasty to treat coronary in-stent restenosis with peri-stent calcium as assessed by optical coherence tomography. EuroIntervention. 2018 May 15. pii: EIJ-D-18-00139. [Epub ahead of print] 

Ali ZA, Karimi Galougahi K, Shlofmitz R, Maehara A, Mintz GS, Abizaid A, Chamié D, Hill J, Serruys PW, Onuma Y, Stone GW. Imaging-guided pre-dilatation, stenting, post-dilatation: a protocolized approach highlighting the importance of intravascular imaging for implantation of bioresorbable scaffolds. Expert Rev Cardiovasc Ther. 2018 Jun;16(6):431-440. 

Lee MS, Shlofmitz E, Goldberg A, Shlofmitz R. Multicenter registry of real-world patients with severely calcified coronary lesions undergoing orbital atherectomy: 1-Year outcomes. J Invasive Cardiol. 2018 Apr;30(4):121-124. 

Lee MS, Shlofmitz RA, Shlofmitz E, Srivastava PK, Kong J, Grines C, Revytak G, Chambers JW. Orbital atherectomy for the treatment of small (2.5mm) severely calcified coronary lesions: ORBIT II sub-analysis. Cardiovasc Revasc Med. 2018 Apr;19(3 Pt A):268-272. 

Lee MS, Shlofmitz RA, Martinsen BJ, Sethi S, Chambers JW. Impact of age following treatment of severely calcified coronary lesions with the orbital atherectomy system: 3-year follow-up. Cardiovasc Revasc Med. 2018 Jan 31. pii: S1553-8389(18)30013-7. [Epub ahead of print] 

Fujino A, Mintz GS, Matsumura M, Lee T, Kim SY, Hoshino M, Usui E, Yonetsu T, Haag E, Shlofmitz RA, Kakuta T, Maehara A A new optical coherence tomography-based calcium scoring system to predict stent under-expansion.. EuroIntervention. 2018 Feb 6. pii: EIJ-D-17-00962. 

Lee MS, Shlofmitz E, Kong J, Lluri G, Srivastava PK, Shlofmitz R. Impact of the use of intravascular imaging on patients who underwent orbital atherectomy. J Invasive Cardiol. 2018 Feb;30(2):77-80. 

Parviz Y, Shlofmitz E, Fall KN, Konigstein M, Maehara A, Jeremias A, Shlofmitz RA, Mintz GS, Ali ZA. Utility of intracoronary imaging in the cardiac catheterization laboratory: comprehensive evaluation with intravascular ultrasound and optical coherence tomography. Br Med Bull. 2018 Jan 19. 

Yamamoto MH, Maehara A, Karimi Galougahi K, Mintz GS, Parviz Y, Kim SS, Koyama K, Amemiya K, Kim SY, Ishida M, Losquadro M, Kirtane AJ, Haag E, Sosa FA, Stone GW, Moses JW, Ochiai M, Shlofmitz RA, Ali ZA. Mechanisms of orbital versus rotational atherectomy plaque modification in severely calcified lesions assessed by optical coherence tomography. JACC Cardiovasc Interv. 2017 Dec 26;10(24):2584-2586. 

Ali ZA, Karimi Galougahi K, Maehara A, Shlofmitz RA, Ben-Yehuda O, Mintz GS, Stone GW. Intracoronary optical coherence tomography 2018: current status and future directions. JACC Cardiovasc Interv. 2017 Dec 26;10(24):2473-2487. 

Lee MS, Anose BM, Martinsen BJ, Lee AC, Shlofmitz RA, Chambers JW. Orbital atherectomy treatment of severely calcified native coronary lesions in patients with prior coronary artery bypass grafting: Acute and one-year outcomes from the ORBIT II trial. Cardiovasc Revasc Med. 2017 Nov 5. pii: S1553-8389(17)30399-8. 

Lee MS, Shlofmitz E, Nayeri A, Hollowed J, Kong J, Shlofmitz RA. Comparison of heparin and bivalirudin in patients undergoing orbital atherectomy. J Invasive Cardiol. 2017 Nov;29(11):397-400. 

Lee MS, Gordin JS, Stone GW, Sharma SK, Saito S, Mahmud E, Chambers J, Généreux P, Shlofmitz R. Orbital and rotational atherectomy during percutaneous coronary intervention for coronary artery calcification. Catheter Cardiovasc Interv. 2017 Oct 17. 

Lee MS, Shlofmitz E, Nayeri A, Hollowed J, Shlofmitz RA. Outcomes of patients with a history of coronary artery bypass grafting who underwent orbital atherectomy for severe coronary artery calcification. J Invasive Cardiol. 2017 Oct;29(10):359-362. 

Shlofmitz E, Martinsen BJ, Lee M, Rao SV, Généreux P, Higgins J, Chambers JW, Kirtane AJ, Brilakis ES, Kandzari DE, Sharma SK, Shlofmitz R. Orbital atherectomy for the treatment of severely calcified coronary lesions: evidence, technique, and best practices. Expert Rev Med Devices. 2017 Nov;14(11):867-879. 

Price MJ, Shlofmitz RA, Spriggs DJ, Haldis TA, Myers P, Popma Almonacid A, Maehara A, Dauler M, Peng Y, Mehran R. Safety and efficacy of the next generation Resolute Onyx zotarolimus-eluting stent: Primary outcome of the RESOLUTE ONYX core trial. Catheter Cardiovasc Interv. 2017 Sep 23. 

Lee MS, Shlofmitz E, Kong J, Srivastava PK, Al Yaseen S, Sosa FA, Gallant M, Shlofmitz R. Outcomes of patients with severely calcified aorto-ostial coronary lesions who underwent orbital atherectomy. J Interv Cardiol. 2017 Sep 4. 

Barbato E, Shlofmitz E, Milkas A, Shlofmitz R, Azzalini L, Colombo A. State of the art: evolving concepts in the treatment of heavily calcified and undilatable coronary stenoses - from debulking to plaque modification, a 40-year-long journey. EuroIntervention. 2017 Aug 25;13(6):696-705. 

Shlofmitz E, Martinsen B, Lee M, Généreux P, Behrens A, Kumar G, Puma J, Shlofmitz R, Chambers J. Utilizing intravascular ultrasound imaging prior to treatment of severely calcified coronary lesions with orbital atherectomy: An ORBIT II sub-analysis. J Interv Cardiol. 2017 Aug 7. 

Lee MS, Martinsen BJ, Lee AC, Behrens AN, Shlofmitz RA, Kim CY, Chambers JW. Impact of diabetes mellitus on procedural and one year clinical outcomes following treatment of severely calcified coronary lesions with the orbital atherectomy system: A subanalysis of the ORBIT II study.. Catheter Cardiovasc Interv. 2017 Jul 22. 

Ramharrack DV, Jurgens CY, Shlofmitz RA. Phenotype of same-day-discharge patients after percutaneous coronary intervention. J Cardiovasc Nurs. 2017 Jul 20. 

Price MJ, Saito S, Shlofmitz RA, Spriggs DJ, Attubato M, McLaurin B, Popma Almonacid A, Brar S, Liu M, Moe E, Mehran R. First report of the resolute onyx 2.0-mm zotarolimus-eluting stent for the treatment of coronary lesions with very small reference vessel diameter. JACC Cardiovasc Interv. 2017 Jul 24;10(14):1381-1388. 

Shlofmitz E, Meraj P, Jauhar R, Sethi SS, Shlofmitz RA, Lee MS. Safety of orbital atherectomy in patients with left ventricular systolic dysfunction. J Interv Cardiol. 2017 Jul 19. 

Lee MS, Shlofmitz E, Lluri G, Kong J, Neverova N, Shlofmitz R. Outcomes of patients with myocardial infarction who underwent orbital atherectomy for severely calcified lesions.. Cardiovasc Revasc Med. 2017 May 7. 

Song L, Mintz GS, Yin D, Yamamoto MH, Chin CY, Matsumura M, Kirtane AJ, Parikh MA, Moses JW, Ali ZA, Shlofmitz RA, Maehara A. Characteristics of early versus late in-stent restenosis in second-generation drug-eluting stents: an optical coherence tomography study. EuroIntervention. 2017 Jun 20;13(3):294-302. 

Song L, Mintz GS, Yin D, Yamamoto MH, Chin CY, Matsumura M, Fall K, Kirtane AJ, Parikh MA, Moses JW, Ali ZA, Shlofmitz RA, Maehara A. Neoatherosclerosis assessed with optical coherence tomography in restenotic bare metal and first- and second-generation drug-eluting stents. Int J Cardiovasc Imaging. 2017 Aug;33(8):1115-1124. 

Chin CY, Matsumura M, Maehara A, Zhang W, Lee CT, Yamamoto MH, Song L, Parviz Y, Jhalani NB, Mohan S, Ratner LE, Cohen DJ, Ben-Yehuda O, Stone GW, Shlofmitz RA, Kakuta T, Mintz GS, Ali ZA. Coronary plaque characteristics in hemodialysis-dependent patients as assessed by optical coherence tomography. Am J Cardiol. 2017 May 1;119(9):1313-1319. 

Lee MS, Park KW, Shlofmitz E, Shlofmitz RA. Comparison of rotational atherectomy versus orbital atherectomy for the treatment of heavily calcified coronary plaques. Am J Cardiol. 2017 May 1;119 (9):1320-1323. 

Lee MS, Nguyen H, Philipson D, Shlofmitz RA. "Single-Operator" technique for advancing the orbital atherectomy device. J Invasive Cardiol. 2017 Mar;29 (3):92-95. 

Lee MS, Martinsen BJ, Shlofmitz R, Shlofmitz E, Lee AC, Chambers J. Orbital atherectomy treatment of severely calcified coronary lesions in patients with impaired left ventricular ejection fraction: one-year outcomes from the ORBIT II study. EuroIntervention. 2017 Jun 20;13(3):329-337. 

Lee M, Généreux P, Shlofmitz R, Phillipson D, Anose BM, Martinsen BJ, Himmelstein SI, Chambers JW. Orbital atherectomy for treating de novo, severely calcified coronary lesions: 3-year results of the pivotal ORBIT II trial. Cardiovasc Revasc Med. 2017 Jun;18(4):261-264. 

Lee MS, Shlofmitz E, Haag E, Santiago L, Pollack S, Reichek N, Shlofmitz RA. Optimal same-day platelet inhibition in patients receiving drug-eluting stents with or without previous maintenance thienopyridine therapy: from the evaluation of platelet inhibition in patients having a verify now assay (EPIPHANY) Trial. Am J Cardiol. 2017 Apr 1;119(7):991-995. 

Lee MS, Nguyen H, Shlofmitz R. Incidence of bradycardia and outcomes of patients who underwent orbital atherectomy without a temporary pacemaker. J Invasive Cardiol. 2017 Feb;29(2):59-62. 

Lee MS, Shlofmitz E, Lluri G, Shlofmitz RA. Outcomes in elderly patients with severely calcified coronary lesions undergoing orbital atherectomy. J Interv Cardiol. 2017 Apr;30(2):134-138. 

Lee MS, Shlofmitz E, Lluri G, Shlofmitz RA. Impact of impaired renal function in patients with severely calcified coronary lesions treated with orbital atherectomy. J Invasive Cardiol. 2017 Jun;29(6):203-206. 

Escaned J, Ryan N, Mejía-Rentería HCook CM, Dehbi HM Alegria-Barrero E, Alghamdi A, Al-Lamee R, Altman J Ambrosia A, Baptista SB, Bertilsson M, Bhindi R Birgander M, Bojara W, Brugaletta S, Buller C, Calais F, Silva PC Carlsson J, Christiansen EH, Danielewicz M, Di Mario C Doh JH, Erglis A Erlinge D, Gerber RT, Going O, Gudmundsdottir I, Härle T Hauer D, Hellig F, Indolfi C, Jakobsen L, Janssens L, Jensen J, Jeremias A, Kåregren A, Karlsson AC Kharbanda RK, Khashaba A, Kikuta Y, Krackhardt F, Koo BK, Koul S, Laine M, Lehman SJ, Lindroos P, Malik IS, Maeng M Matsuo H, Meuwissen M, Nam CW, Niccoli G, Nijjer SS, Olsson H, Olsson SE,Omerovic E, Panayi G, Petraco R, Piek JJ, Ribichini F, Samady H, Samuels B, Sandhall L, Sapontis J, Sen S,Seto AH, Sezer M, Sharp ASP, Shin ES, Singh J, Takashima H, Talwar S, Tanaka N, Tang K, Van Belle E, van Royen N, Varenhorst C, Vinhas H, Vrints CJ, Walters D, Yokoi H, Fröbert O, Patel MR, Serruys P, Davies JE, Götberg M. Safety of the deferral of coronary revascularization on the basis of instantaneous wave-free ratio and fractional flow reserve measurements in stable coronary artery disease and acute coronary syndromes. JACC 2018 Aug 13;11(15):1437-1449. doi: 10.1016/j.jcin.2018.05.029. 

Shah SV, Zimmermann FM, Johnson NP, Nishi T, Kobayashi Y, Witt N, Berry C, Jeremias A, Koo BK, Esposito G, Rioufol G, Park SJ, Oldroyd KG, Barbato E, Pijls NHJ, De Bruyne B, Fearon WF; CONTRAST Study Investigators. Sex differences in adenosine-free coronary pressure indexes: A CONTRAST substudy. JACC Cardiovasc Interv. 2018 Aug 13;11(15):1454-1463.

Ali ZA, Parviz Y, Brinkman M, Matsumura M, Redfors B, Brogno DA, Corral MD, Fall KN, Mintz GS, Stone GW, Maehara A, Jeremias A, Kirtane AJ. Pressure wire compared to microcatheter sensing for coronary fractional flow reserve: the PERFORM study. EuroIntervention. 2018 Jul 20;14(4):e459-e466.

Parikh PB, Novotny S, Jeremias A, Butler J, Yang J, Yin D, Gruberg L. Impact of chronic kidney disease on mortality in adults undergoing balloon aortic valvuloplasty. Cardiovasc Revasc Med. 2018 Jun;19(4):448-451. 

Svanerud J, Ahn JM, Jeremias A, van 't Veer M, Gore A, Maehara A, Crowley A, Pijls NHJ, De Bruyne B, Johnson NP, Hennigan B, Watkins S, Berry C, Oldroyd KG, Park SJ, Ali ZA.

Validation of a novel non-hyperaemic index of coronary artery stenosis severity: the Resting Full-cycle Ratio (VALIDATE RFR) study. EuroIntervention. 2018 May 23. pii: EIJ-D-18-00342.

Shlofmitz E, Sosa F, Goldberg A, Maehara A, Ali ZA, Mintz GS, Moses JW, Stone GW, Shlofmitz RA, Jeremias A. Bifurcation and ostial optical coherence tomography mapping (BOOM) - Case description of a novel bifurcation stent technique. Cardiovasc Revasc Med. 2018 May 6. pii: S1553-8389(18)30185-4.

Lima FV, Gruberg L, Aslam U, Ramgadoo M, Clase K, Trevisan A, Jeremias A.

The impact of unfractionated heparin or bivalirudin on patients with stable coronary artery disease undergoing percutaneous coronary intervention. J Interv Cardiol. 2018 Apr;31(2):177-184.

Matsumura M, Maehara A, Johnson NP, Fearon WF, De Bruyne B, Oldroyd KG, Pijls NHJ, Jenkins P, Ali ZA, Mintz GS, Stone GW, Jeremias A. Qualitative resting coronary pressure wave form analysis to predict fractional flow reserve. EuroIntervention. 2018 Mar 27. pii: EIJ-D-17-01149.

Cook CM, Jeremias A, Petraco R, Sen S, Nijjer S, Shun-Shin MJ, Ahmad Y, de Waard G, van de Hoef T, Echavarria-Pinto M, van Lavieren M, Al Lamee R, Kikuta Y, Shiono Y, Buch A, Meuwissen M, Danad I, Knaapen P, Maehara A, Koo BK, Mintz GS, Escaned J, Stone GW, Francis DP, Mayet J, Piek JJ, van Royen N, Davies JE. Fractional flow reserve/instantaneous wave-free Rratio discordance in angiographically intermediate coronary stenoses: An analysis using doppler-derived coronary flow measurements. JACC Cardiovasc Interv. 2017 Dec 26;10(24):2514-2524.

Fearon WF, Chambers JW, Seto AH, Sarembock IJ, Raveendran G, Sakarovitch C, Yang L, Desai M, Jeremias A, Price MJ; ACIST-FFR Study Investigators. ACIST-FFR Study (Assessment of catheter-based interrogation and standard techniques for fractional flow reserve Measurement). Circ Cardiovasc Interv. 2017 Dec;10(12). pii: e005905.

Kobayashi Y, Johnson NP, Zimmermann FM, Witt N, Berry C, Jeremias A, Koo BK, Esposito G, Rioufol G, Park SJ, Nishi T, Choi DH, Oldroyd KG, Barbato E, Pijls NHJ, De Bruyne B, Fearon WF; CONTRAST Study Investigators. Agreement of the resting distal to aortic coronary pressure With the instantaneous wave-free ratio. J Am Coll Cardiol. 2017 Oct 24;70(17):2105-2113

Nishi T, Johnson NP, De Bruyne B, Berry C, Gould KL, Jeremias A, Oldroyd KG, Kobayashi Y, Choi DH, Pijls NHJ, Fearon WF; CONTRAST Study Investigators. Influence of contrast media dose and osmolality on the diagnostic performance of contrast fractional flow reserve. Circ Cardiovasc Interv. 2017 Oct;10(10). pii: e004985. 

Matsumura M, Johnson NP, Fearon WF, Mintz GS, Stone GW, Oldroyd KG, De Bruyne B, Pijls NHJ, Maehara A, Jeremias A. Accuracy of fractional flow reserve measurements in clinical practice: Observations From a core laboratory analysis. JACC Cardiovasc Interv. 2017 Jul 24;10(14):1392-1401.

Davies JE, Sen S, Dehbi HM, Al-Lamee R, Petraco R, Nijjer SS, Bhindi R, Lehman SJ, Walters D, Sapontis J, Janssens L, Vrints CJ, Khashaba A, Laine M, Van Belle E, Krackhardt F, Bojara W, Going O, Härle T, Indolfi C, Niccoli G, Ribichini F, Tanaka N, Yokoi H, Takashima H, Kikuta Y, Erglis A, Vinhas H, Canas Silva P, Baptista SB, Alghamdi A, Hellig F, Koo BK, Nam CW, Shin ES, Doh JH, Brugaletta S, Alegria-Barrero E, Meuwissen M, Piek JJ, van Royen N, Sezer M, Di Mario C, Gerber RT, Malik IS, Sharp ASP, Talwar S, Tang K, Samady H, Altman J, Seto AH, Singh J, Jeremias A, Matsuo H, Kharbanda RK, Patel MR, Serruys P, Escaned J. Use of the Instantaneous wave-free ratio or fractional flow reserve in PCI. N Engl J Med. 2017 May 11;376(19):1824-1834

Gargiulo G, Stabile E, Ferrone M, Barbato E, Zimmermann FM, Adjedj J, Hennigan B, Matsumura M, Johnson NP, Fearon WF, Jeremias A, Trimarco B, Esposito G; CONTRST Study Investigators. Diabetes does not impact the diagnostic performance of contrast-based fractional flow reserve: insights from the CONTRAST study. Cardiovasc Diabetol. 2017 Jan 13;16(1):7

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